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Março 2013 

Study: Pubic Hair Removal May Facilitate Spread Of Molluscum Cantagiosum.

The Los Angeles Times (3/18, Healy) reports, "Writing in a sister publication of the British Medical Journal, two French dermatologists and a global health researcher from Emory University have suggested that an upsurge in the spread of the sexually transmitted molluscum cantagiosum virus over the last decade may be attributable to the trend of shaving or waxing the hair around the genitals." The three studied a group of 30 adults "who sought treatment for lesions in and around their genital area in a clinic in Nice, France," and of those 24 men and six women, 93% used "shaving, clipping or waxing the hair in their genital region." In a letter to Sexually Transmitted Infections, which is published by BMJ, the group wrote that the practice could facilitate the spread of not only the molluscum contagiosum virus, but potentially condylomas as well.

HealthDay (3/19, Mozes) reports that while "One-third of the patients suffered from an assortment of other skin issues, such as warts, bacterial skin infections, cysts, scars, and/or ingrown hairs," the authors theorized that the spread of molluscum contagiosum, a pox virus, "may have spread through 'self-infection,' meaning scratching irritated skin, which was likely provoked by the hair removal process." The hair removal trend has seen positive impacts, as well, according to some researchers; HealthDay notes that "Bloomberg News recently reported that with 80 percent of American college students now waxing, clipping, and shaving away all or some of their genital hair, pubic lice cases have dramatically dropped."

Outubro 2012

Sildenafil Citrate May Improve Sexual Function After RT For Prostate Cancer.
HealthDay (10/30, Preidt) reports, "Prostate cancer patients who received Viagra [sildenafil citrate] before and after their radiation therapy [RT] had improved sexual function, according to a new study" that was scheduled to be presented at an American Society for Radiation Oncology meeting. Participating in the study were "patients with prostate cancer that had not spread who underwent external-beam radiation therapy and/or permanent implantation of radioactive 'seeds.'" Participants "were randomly assigned to take either a 50-milligram-a-day dose of Viagra...or an inactive placebo during treatment and for six months after therapy."

Medscape (10/30, Mulcahy) reports, "Among the 144 patients, overall self-reported erectile function scores (measured on the International Index of Erectile Function [IIEF]) were significantly higher in the sildenafil group than in the placebo 6 months (58.6 vs 49.4; P = .006), 12 months (56.3 vs 48.2; P = .02), and 24 months (54.9 vs. 47.6; P = .04) after therapy."

Agosto 2012

Iced Tea May Raise Kidney Stone Risk.

HealthDay (8/8) reports, "People who drink iced tea may be putting themselves at greater risk for developing painful kidney stones," according to new research from Loyola University Medical Center. The authors of the study "explained the popular summertime drink contains high levels of oxalate, a chemical that leads to the formation of small crystals made of minerals and salt found in urine. Although these crystals are usually harmless...they can grow large enough to become lodged in the small tubes that drain urine from the kidney to the bladder."

Julho 2012

Recreational Use Of ED Drugs May Be Linked To Increased Risk Of Psychogenic ED.
WebMD (7/21, Doheny) reports, "Men who use erectile dysfunction (ED) drugs recreationally may be more likely to develop psychogenic ED, the type that originates in the mind, according to new research" published in the Journal of Sexual Medicine. For the study, investigators evaluated more than 1,200 males. Researcher Christopher Harte, PhD, said, "Among young, healthy men who used ED medicines recreationally, the more frequent ED medicine use was associated with lower confidence in achieving and maintaining erections, which in turn was associated with lower erectile function."

Propecia May Lead To Long-Lasting Sexual Dysfunction.
NBC Nightly News
(7/12, story 5, 2:35, Williams) reported, "Propecia, [is] made by Merck, and did $134 million in sales for them last year, but tonight reports about many possible side effects." NBC Chief Medical Editor Dr. Nancy Snyderman, "Propecia was originally approved by the FDA to treat benign prostate problems and a welcome side effect was hair growth. So in 1997 the FDA approved it to treat male pattern baldness but an unwelcome problem has been sexual dysfunction. Today the FDA charges that the side effects could be permanent." Dr. Michael Irwig of George Washington University's study "involved only 54 men, but 96% experienced sexual dysfunction months after stopping the medication.
ABC World News (7/12, story 8, 2:00, Sawyer) reported, "It's long been known that Propecia can cause side effects, but today researchers at George Washington University reported that problems with sexual function may continue even if you stop taking the drug." ABC (Harris) added, "The before and after shots are compelling: Propecia growing back hair. But the twist, this drug that men take to stay sexually attractive, may, in some cases, be permanently damaging their sex life." The
Time (7/13, Sifferlin) "Healthland" blog reports that according to research published in the Journal of Sexual Medicine finds that sexual side effects from Propecia (finasteride) "may not only continue after stopping finasteride, but they may last for months or even years." In the study, "the patients reported a variety of sexual problems including erectile dysfunction, low libido, trouble having an orgasm, and shrinking and painful genitals. Some men also reported neurological problems like depression, anxiety and cognitive haziness."

Junho 2012

Increasing Number Of US Adolescents Now Diagnosed With Kidney Stones.
Reuters (6/9, Norton) reported that according to a study published online May 16 in the Journal of Urology, an increasing number of adolescents are now receiving diagnoses of kidney stones, with the number of new kidney stone diagnoses climbing six percent annuallyamong young people ages 12 to 17. Researchers are unsure, however, if the incidence of kidney stones among teens is actually increasing or if highly sensitive CT scans are picking up stones that would not have been seen until now.

Junho 2011

Diabetic Men Often Require Invasive Treatments To Manage Erectile Dysfunction.
Medscape (5/26, Stein) reported that diabetic men are "significantly more likely to require invasive second- and third-line therapies to manage erectile dysfunction (ED) than nondiabetic men," according to findings presented at the American Urological Association meeting. After reviewing "medical-claims data from 136,306 men identified from the Innovus i3 database," researchers found that diabetic men were "more than 50% more likely than nondiabetic men to progress to secondary therapies, such as penile suppositories or injectables, within five years of an ED diagnosis." Diabetic men were also "more than twice as likely to undergo tertiary therapy involving penile prosthesis surgery."

Fevereiro 2011

Diabetic Patients May Have Increased Risk For Kidney Cancer.
MedWire (2/10, Albert) reported, "Patients with diabetes have a significantly increased risk for developing kidney cancer compared with nondiabetics," according to a meta-analysis in the journal Diabetologia. The analysis based, on a "combined total of 5,769,987 patients," found that in comparison with "nondiabetic controls, patients with diabetes had a significant 42% increase in relative risk for kidney cancer." This association was stronger in "diabetic women than in diabetic men, with a 70% versus 26% increase in relative risk compared." The researchers noted, however, that "significant heterogeneity between the studies was observed" and called for additional "large cohort studies that adjust for obesity and other potential confounders as well as assessing latency between diabetes and kidney cancer are needed to establish a potential causal relationship between diabetes and kidney cancer risk."

Mycophenolate Mofetil for Interstitial Cystitis

Kidney Stones and Subclinical Atherosclerosis

Free PSA: What Role Does it Have in Evaluating Ca

Dutasteride Not Approved for Cancer Prevention

Belgian case–control study on bladder cancer risk
Eating Over 53g Of Cheese A Day May Increase Risk Of Bladder Cancer.
The UK's Daily Mail (2/10) reports, "A daily helping of cheese could increase the risk of bladder cancer," according to a study in the European Journal of Cancer. Researchers "studied the eating habits of 200 bladder cancer victims and compared them with 386 volunteers who had not developed tumours." They found that "eating cheese had little effect unless the amount exceeded 53g a day. After that, the risk went up by more than half." 

Quadrivalent HPV Vaccine May Be Effective in Young Men CME/CE
Medscape Education Clinical Briefs, February 3, 2011 

Antibiotics, Alpha-Blockers Most Effective Treatment of Chronic Prostatitis/Pelvic Pain Syndrome CME/CE 
Medscape Education Clinical Briefs, January 10, 2011

Neoadjuvant Radiotherapy for Locally Advanced and High-Risk Prostate Cancer CME 
Nature Reviews Clinical Oncology, December 21, 2010 

Contemporary Management of Low-Risk Bladder Cancer CME 
Nature Reviews Urology, January 13, 2011

High BMI, Low PSA Levels Could Mask Prostate Cancer Diagnosis In Obese Men.
MedWire (1/28, Guy) reported, "Obesity is associated with low prostate-specific antigen (PSA) levels and a slow rate" of PSA change, according to a study in Cancer Epidemiology Biomarkers and Prevention. The study indicated that having a BMI of "at least 30 kg/m2" was associated with having a "large prostate volume, increased plasma volume, and increased age-adjusted changes in plasma volume over time. ... 'These findings suggest that men with higher BMIs may be less likely to be screened for prostate cancer, because of consistently lower PSA levels,'" the researchers wrote. Therefore, they noted, fewer cancers "are then detected in obese men due to their larger prostate size" or delayed diagnoses, resulting in "more-aggressive disease at diagnosis." Their conclusions were based on a study "545 men" during "eight rounds of biennial follow-up from 1990."

"Definitive" Study On Effectiveness Of Cranberry Juice Raises More Questions.
The results were published this month in Clinical Infectious Diseases. After six months, the women in the placebo group had 23 new infections and those in the cranberry group had 31, a statistically insignificant difference. The juice apparently offered no protection. 
“It is still a big question” 

Janeiro 2011

All Nonsteroidal Anti-Inflammatory Drugs Have Cardiovascular Risks
A new study has put the well-known pain relievers back in the headlines, with data showing that all NSAIDs increase the risk for cardiovascular events.
Several earlier meta-analyses were unable to resolve the debate over risk because they failed to include all randomized evidence in 1 study. This new network meta-analysis,
published online January 11 in BMJ, includes all available evidence.
Clinical Review, January 2011.

Warm Vs Cold Ischemia During Open Partial Nephrectomy for Tumor in a Solitary Kidney 
It has long been believed that reducing ischemia time using cold slush solutions helps preserve renal function but does it really matter if the duration of renal pedicle clamping is relatively short? In a multi-institutional, retrospective study Lane et al (
page 421) examined 660 patients who underwent partial nephrectomy at 4 different centers, of whom 360 were subjected to warm ischemia and 300 to cold ischemia. Mean ischemia times were 22 and 45 minutes, respectively. At 3 months after partial nephrectomy median glomerular filtration rate decreased by 22% and 21% with warm vs cold ischemia, respectively. In a multivariate analysis increased age, larger tumor size, lower preoperative glomerular filtration rate, less parenchymal preservation and longer ischemia time were associated with decreased postoperative glomerular filtration rate. The authors conclude that patients experiencing warm ischemia times of less than 30 minutes have outcomes similar to those subjected to icing solutions. Obviously, no ischemia (nonclamping) would potentially be best. In addition, better preservation rates of renal parenchyma and a prospective randomized study would help clarify this hypothesis.

Association of Nocturia and Mortality

Paclitaxel Hyaluronic Ac. for Intravesical Therapy

The Effect of Dutasteride on the Usefulness of PSA

The Novel Prostate Cancer Antigen 3 (PCA3) Biomark

Phyllanthus niruri as a Promising Treatment
Chá Quebra Pedras

LECO in The Treatment of Pediatric Urolithiasis
Dezembro 2010

ADT Associated With Increased Risk For Cataracts In Older Prostate Cancer Patients.
Reuters (12/28, Peeples) reports that, according to a study published online in the Annals of Epidemiology, prostate cancer patients over the age of 65 who choose to undergo androgen-deprivation therapy (ADT) to fight their disease may have a somewhat higher risk of developing cataracts. Researchers arrived at that conclusion after examining data on 66,000 patients with prostate cancer. They found that over time, patients on ADT incurred a 9% increase in risk for cataracts, compared to patients not on ADT. The study authors pointed out that patients on ADT face a higher risk of obesity and diabetes and that both conditions on their own raise the risk for cataracts. 
Prostate Cancer Risk Calculator May Underestimate High-Grade Disease.
MedWire (12/23, Guy) reported, "Caution is required when applying the prostate cancer risk calculator (PCRC) to patients with suspected prostate cancer as it may underestimate their risk for high-grade disease," researchers warned in a study published in the Journal of Urology. MedWire said that "when Tin Ngo and colleagues from Stanford University School of Medicine, California updated the calculator in a contemporary cohort of 619 patients who underwent 12-core biopsy, not sextant biopsy (as in the PCPT), they found their version better able to predict high-grade disease than the PCPT version." Notably, "the risk predictions for high-grade disease using the Stanford cohort were well above those calculated by the PCPT."
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